Childhood brain tumor traced to normal casey johnson stem cells gone bad
An aggressive childhood
Brain Tumor known as medulloblastoma originates in normal brain “stem” cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).
www.google.comReporting in the Aug. 12 issue of Cancer Cell, the scientists say they have uncovered new origins for these tumors from early stem cells as well as more mature cells. Previously, scientists had assumed the tumors might only come from a single source: more mature cells which become neurons and do not have “stem” cell properties. The findings hint at potential new treatment approaches for medulloblastoma by targeting the origins of the tumors, and further suggest that not all patients’ tumors may be born from the same cells casey johnson.
“We now have a better idea of where these
Brain Tumor Symptomss come from and their relationship to normal stem cells in the brain casey johnson,” said Keith Ligon, MD, PhD, co-senior author of the report and an investigator at the Center for Molecular Oncologic Pathology at Dana-Farber and the Brigham and Women’s Hospital in Boston.
Co-senior author, David Rowitch, MD, PhD, currently a professor of pediatrics and neurosurgery at UCSF and a Howard Hughes Medical Institute investigator, commented that mouse experiments shed light on how normal stem cells – cells with the power to create all types of cells in the brain – can be transformed into tumors. The transformation occurs when a cell-signaling pathway known as Sonic hedgehog (named for a cartoon character) is reactivated by a chance mutation.
Sonic hedgehog plays an important role during the embryonic development of the brain, but normally shuts down when it’s no longer needed. When turned on again by a mutation, the signals can trigger cell processes leading to tumors – not just in the brain, but in other organs as well.
www.yahoo.comMedulloblastomas, usually diagnosed in children between 2 and 5 years of age, affect the brain’s cerebellum region, which is involved in controlling body movements. They make up about 30 percent of childhood
Brain Tumors, and account for 250 to 300 new cases per year.
With current treatments, approximately 60 to 70 percent of patients live at least five years, but often they are left with cognitive disabilities from surgery, chemotherapy and radiation, urgently suggesting a need for new, more-selective therapies.
“Medulloblastoma was one of the first tumors that was believed to fit the hypothesis that tumors are caused by ‘cancer stem cells’ that initiate malignancies and sustain them,” said Ligon, who is also on the faculty and an assistant professor at Harvard Medical School casey johnson. “But the prevailing hypothesis — that medulloblastomas originate from non-stem cells -- just did not make perfect sense with this.”
Despite countless studies that link cell phone radiation to
brain tumor treatments and cancer, the people in charge have tried in earnest to convince us that “more evidence is needed.”
Obviously not the Cell Phone Industry. When a 1993 lawsuit against the industry was waged by a Florida man who claimed that his wife died of a
Brain Tumor caused by her cell phone (the brain tumor happened to be shaped like her cell phone antenna), the government had to administer a slap on the wrist. And they did. A tiny one.
